Pdss2 kd/kd line G mice: two line G mice that had high-urine albumin also had low renal CoQ9 content, whereas six line G mice that did not manifest evidence of nephritis all had high-renal CoQ9 content (Saiki et al, 2008).
By mating with WT mice, three lines were established, designated CD97 Tg1, CD97 Tg2, and CD97 Tg3 (in short, Tg1 to Tg3).
We orthotopically transplanted into immune-competent WAP-T mice two tumor cell lines (H8N8, moderately metastatic, and G-2, non-metastatic), developed from primary WAP-T tumors.
In order to delete genes in the mouse mammary gland specifically, two lines of mice have been created that express Cre recombinase under the control of mammary-specific promoters in the laboratory of Lothar Hennighausen (NIDDK).
Out of 21 independent Epstein-Barr virus (EBV) latent membrane protein 1 (LMP1) transgenic mice, one mouse line exhibited intriguing phenotypes showing growth retardation, alopecia and short lifespan in homozygotes (−/−; Figure 1A C), and signs of haploinsufficiency for heterozygotes for the alopecia (Figure 1A).
We next established the Cp-GFP/mdx mouse model through crossing the two lines of mice and examined Cp-GFP expression.
We obtained three lines of PLP-NCre-mice (PCNA, PCNC, PCND), two lines of PLP-CCre mice (PCCK, PCCR), four lines of GFAP-NCre- (GCNQ, GCNT, GCNV, GCNW) as well as one GFAP-CCre-mouse line (GCCF) (Text S1).
Amongst nine transmitting mouse lines, five lines expressed the DBD-TAD mRNA, but only one of them showed detectable TAD protein expression.
Transcriptomes of CCl4-treated BXD lines were analyzed in female mice (three arrays per line) because they showed more pronounced differences in fibrosis progression among the BXD lines.
Here we have focused on characterizing the first two lines of mice.
