Ablation of the α1 subunit in global GABAARα1 KO mice triggers a dramatic increase in the density of postsynaptic sites expressing GABAARα3 in the ML, which has been interpreted as a reorganization of cerebellar networks [35].
In vivo, FP administration to chronically diabetic mice triggered (1) a significant elevation of insulin and C-peptide levels, (2) the formation of insulin-containing cell clusters in livers, and (3) a systemic anti-inflammatory shift (higher Foxp3+CD4+CD25+ T cell frequencies, elevated rates of IL-10-producing cells, and reduced rates of IFN-γ-secreting cells).
Here, we show that intracerebroventricular infusion of AD-associated Aβ oligomers (AβOs) in mice triggered peripheral glucose intolerance, a phenomenon further verified in two transgenic mouse models of AD.
Strikingly, we observed that depletion of neutrophils in MCMV-infected RAG−/− mice triggered dramatic weight loss and a concurrent large elevation in replicating virus in the livers and lungs.
It is likely that disturbances in the homeostasis of RPE cells, due to accumulation of undegraded intracellular material in the cKO mice, trigger a para-inflammatory response in an attempt to restore normal RPE function.
Applying a chemical that stimulates cell division to the skin of the mice triggered more bursts of ERK activity; whereas fewer bursts were observed if Hiratsuka et al. used other chemicals to block the activity of some of the signaling proteins that work upstream of ERK.
It was hypothetically possible that injection of cognate peptide into a single chain TCRα and TCRαβ transgenic mice had triggered a cytokine storm due to the large number of responding T cells, and this had in turn caused thymic apoptosis leading randomly to a skewed cytokine outcome in surviving cells.
The in vivo results suggested that SPION-PEG2000 administration in mice triggered liver and kidney injury.
Antibiotic treatment of adult mice triggered sexually biased microglial responses revealing both acute and long-term effects of microbiota depletion.
Injections of the cells into mice triggered no tumors, she also reported, and the cells survived for more than 6 months when transplanted into monkeys.
