Drug companies use such mice to test experimental drugs in new ways, and scientists use them to gain insights into basic biological questions such as how the brain develops in the embryo and the immune system defends against invaders.
When Harvard biologists in the early 1900's needed mice to test Mendel's newly discovered laws, they bought mouse strains from Abbie Lathrop, a retired school teacher who bred fancy mice on her farm in Granby, Mass.
Sometimes, patient tumors do not grow in the mice at all, and it takes at least four months to create enough mice to test a reasonable number of drugs.
Thesleff and her team used genetically engineered mice to test their hypothesis.
As such, it is often used as xenografts in nude mice to test new drugs and therapeutic strategies against breast cancer.
They were injecting an irritant into the feet of mice to test their pain response, but the rodents didn't seem to feel anything.
Additional studies utilized inducible cardiac Sav1 and Lats1/2 CKO mice to test whether these Hippo pathway components could also influence the regenerative capacity of the mammalian heart [125].
A model shed antigen, ovalbumin (OVA), was co-delivered with polymeric biomaterial carrier vehicles in C57BL6 mice to test whether the presence of the biomaterial acted as an adjuvant in the immune response towards the associated antigen.
Here, we developed a xenograft model in which cells from 14 samples of human ovarian serous adenocarcinoma tissue or ascites were implanted in immunodeficient mice to test the tumorigenic potential of different populations of ovarian cancer cells.
If you're using mice to test a new drug for diabetes, a chronic disease, monitoring glucose levels for only a week after administering the drug will undermine your case for the drug's effectiveness.
In this issue of Cancer Cell, Gannon and colleagues create genetically engineered mice to test the role phosphorylation plays in the modification of one serine long thought to play a critical role in controlling the activity of MDM2, one of p53's main negative regulators.
