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It has been shown in mice to reduce a BCC biomarker and to reduce growth of BCCs.
In the present study, we used immunodeficient NOD-scid mice to reduce confounds of xenograft rejection, avoid immunosuppressant drugs, and enhance hCNS-SCns engraftment success.
Moreover, blockade of ICOS-L was shown in mice to reduce lupus nephritis [ 75].
In contrast, pairing ob/ ob with normal mice caused the ob/ ob mice to reduce their food intake to that observed in the normal normal pairing [ 5].
Two successful Sun2 +/− germline-transmitted litters were obtained and were then crossed with WT C57BL/6Nar1 mice to reduce the genetic background of 129/Sv.
Endotrophin levels in PyMT mice were modulated genetically with MMTV-endotrophin transgenic mice for overexpression and with COL6−/− mice to reduce the levels.
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Importantly, metabolic interventions that increase longevity in mice tend to reduce the incidence of cancer (Serrano and Blasco, 2007).
Years later, the antibody was changed to make it chimeric - part human, part mouse - to reduce the immune reactions in patients.
This methodology requires sufficient backcrossing in a particular mouse strain to reduce the mixed genetic background.
The membrane repair assay was performed by a technician blinded to the mouse cohorts to reduce any potential for bias.
In addition, the deletion mutants used later in competition tests were recovered as pools from infected mice, to further reduce risks of attenuation.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com