Exact(5)
But several prominent cases have shown the flaws in using mice to predict reactions in humans.
The Perlegen database utilized sequence data from 55 inbred strains of mice to predict haplotypes using pairwise comparisons between mouse strains.
Machado, Darmohray et al.'s analysis revealed that these movements likely resulted from a failure of the cerebellum of the mutant mice to predict and compensate for the motion of the rest of the body.
We fit our model to several published data sets of deficient regeneration in rats and healthy regeneration in humans, rats, and mice to predict differences in molecular regulation in disease states and across species.
Their statement, on the failure of mice to predict for man in an important area of pharmacology, should be taken seriously and also serve as food for thought in toxicology.
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Furthermore, a method developed by Ritchie et al. uses expression patterns conserved between human and mouse to predict miRNA targets more accurately [ 30].
Although these studies did not measure lithium levels during treatment, we used pharmacokinetic modeling and simulation, based on reported parameter estimates for lithium in mice [15], to predict plasma lithium levels for the dosing regimens used.
Contextual memory capability was tested by a fear conditioning paradigm in which mice learn to predict aversive events (mild electric shock).
As an important part of bioluminescence tomography, which is a newly developed optical imaging modality, mouse optical simulation environment (MOSE) is developed to simulate bioluminescent phenomena in the living mouse and to predict bioluminescent signals detectable outside the mouse.
Next, I evaluated the ability of data from non-cardiac mouse tissues to predict E11.5 heart enhancers.
To model this situation, I evaluated the efficacy of using H3K4me1 and H3K27ac collected in mouse hearts to predict known human heart enhancers.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com