Sentence examples for mice to overcome from inspiring English sources

Adding optogenetic stimulation on certain trials allows mice to overcome this inherent bias.

For several of these mouse models, treatment with drugs enable adult mice to overcome both their cognitive and social interaction deficits (Ehninger et al., 2008; Castren et al., 2012).

When we add our optogenetic manipulation, we see that the main effect of stimulation at the optimal phase is to allow mice to overcome their bias toward returning to the rewarded arm.

Intriguingly, a mitoTALEN system was recently used in mice to overcome mitochondria heteroplasmy by targeting and selectively destroying diseased mitochondria but still allowing for the transmission of wild-type mitochondria in mouse oocytes from the original mother [ 20].

Further transmission of brains from clinically affected pigs to pigs or poTg mice to overcome the species barrier would be necessary to determine whether these pigs were indeed affected by a prion disease.

Cervidized Prnp transgenic mouse brain homogenate can support CWD prion replication (32 ), and extensive in vitro conditioning of a CWD isolate by PMCA in a cervidized substrate (or passage in cervidized mice) was sufficient to overcome the barrier and enable efficient in vitro amplification in a humanized transgenic mouse substrate (33 ).

Currently, specific knockout mice are used to overcome the immune tolerance associated with self-antigens.

Along this line, the idea of the immunization of "knock-out" mice was proposed to overcome the problem of inter-species sequence similarity in antibody production [5].

The generation of different KAR specific knock-out (KO) mice partially helped to overcome this drawback [14], [15] and their characterization yielded insights into KAR physiology.

Using AQP4 null mice, we checked for antibody production and T cell responses against peptides corresponding to the extracellular loops of AQP4, loops A, C and E. AQP4 null mice were used in this model because these mice do not have to overcome immune tolerance to develop pathogenic AQP4-reactive T cells.

Although it is possible that the dual roles of CD14 as a mediator of the pathogenesis of ECM and a positive regulator of parasite density operate independent of each other, our results suggest that CD14-mediated pathogenesis of ECM is directly dependent on the level of parasitemia; CD14-KO mice that were able to overcome resistance to ECM (n = 4) had a parasite burden similar to WT mice.