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When injected under the skin of diabetic mice, they induced the body to build a blood supply to them and enabled the mice to live longer.
These and other positive health effects enable the obese mice to live 44 percent longer, on average, than obese mice that did not receive the drug, according to a team of researchers led by Rafael de Cabo, a gerontologist at the National Institute on Aging.
The drug also allowed 70% of mice to live through an infection with the bacterium Staphylococcus aureus, which can cause sepsis in humans.
The scientists allowed some of the mice to live up to 12 months--midlife for a mouse--before sacrificing them and examining the pancreas.
In a new study, researchers report that an antibiotic called rapamycin--after the island's Polynesian name, Rapa Nui--enabled middle-aged mice to live up to 16% longer than their rapa-free counterparts.
This suggests that adaptations occurred to allow these mice to live with elevated n-3 fatty acid levels.
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The mice seem to live longer because they are somehow protected from the usual diseases that kill them.
PBS liposome-treated Tg+ mice continued to live past day 162, suggesting that toxicity is directly attributable to the clodronate and not to liposomes.
Female house mice tend to live in extended family groups and can nest communally and nurse offspring communally (reviewed in König and Lindholm, 2012).
There is a mammalian precedent for this: dwarf mice tend to live longer than their larger littermates (Bartke et al. 2001).
The oldest mouse ever to live was called Yoda.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com