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In Experiment 1, we tested the hypothesis that Gatorade or Red Bull might cause or allow mice to increase their voluntary wheel running.
To test that hypothesis, Schafer applied pharmacological agents to the eyes of developing mice to increase or decrease the firing activity of neurons in one eye, and found that the less active synaptic connections were more aggressively eaten and pruned by microglia.
In one cohort (cohort 3), the wild-type, control animals were supplemented with separately bred C57Bl6 mice to increase available numbers.
Heterozygous Cx30T5M mice were backcrossed with C57BL/6 mice to increase the C57BL/6 genetic background.
Both original transgenic lines were crossed with hairless albino mice to increase any bioluminescence signals through the skin that originate from deeper structures.
By requiring mice to increase peak press frequency in order to obtain reward, the authors found that variability in press frequency is selectively decreased.
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Conversely, loss of function variants of human PCSK9 or inactivation of the mouse Pcsk9 gene, lead to decreased plasma LDL-C [11], [12], and in mice to increased hepatic LDLR protein [13], [14].
Exposure of EC from WT mice to increasing concentrations of the wild-type strain of P. aeruginosa for 4 hours elicited increasing amounts of KC and IL-6, but not of TNF-α or G-CSF (data not shown).
This could be an adaptive response of the mice to increasing oxidative stress induced by DMBA/TPA application.
A series of experiments was designed to determine if disease would also be suppressed by exposing fetal NZB/NZW mice to increased testosterone.
The ability of the gut microbiota from obese mice to predispose lean mice to increased weight gain has been linked to increased energy harvesting capacity (Turnbaugh et al, 2006; Bäckhed, 2012).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com