The goal was to give the animals human-like immune systems, so that FDA researchers could use the mice to evaluate the safety and efficacy of various drugs.
The rSE was then grafted to the dorsum of SCID mice to evaluate its biocompatibility by histologic and immunohistochemistry analysis.
Then three transdermal doses (10, 20 and 40 mg/kg) were administered to mice to evaluate pharmacological activity.
Besides, material/BMSCs composites were implanted into the subcutaneous of back of nude mice to evaluate the osteoconductive property of the material.
Furthermore, both PDLSC and JBMMSC sheets obtained from each optimized technique were transplanted subcutaneously into nude mice to evaluate their capacity for ectopic bone regeneration.
MRL/lpr Fn14 knockout (KO) lupus mice were compared with MRL/lpr Fn14 wild-type (WT) mice to evaluate for any possible differences in the severity of cutaneous lesions and the presence of infiltrating immune cells.
In this study, we applied bi-layer gelatin chondrointin-6-sulfate hyaluronic acid (gelatin chondrointin-6-sulfate hyaluronicre combined immunodeficiency (SCID) mice to evaluate its effect on promotingelatin chondrointin-6-sulfate hyaluronic
The scaffolds pre-cultured with U-87 MG and C6 cells were then implanted into nude mice to evaluate tumor growth and blood vessel recruitment compared to the standard 2D cell culture and 3D Matrigel matrix xenograft controls.
Cancer biologists utilize several mouse models of cancer (xenografts, syngeneic mice, or genetically engineered mice) to evaluate tumor biology, efficacy, and toxicity of drugs; validate disease pathways; and identify translational biomarkers.
The amino acids were analyzed after pre-column derivatization with 4-fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) and detected by the fluorescence detector and MS. The systems were applied to the urine of d-amino acid oxidase (DAO) deficient B6DAO− mice and control C57BL mice to evaluate the presence and metabolism of the Cit and Orn enantiomers in mammals.
In and administered to BALB/c mice to evaluate the biodistribution of nanotubes [80].
