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We investigated alloreactivity of human CD8+ T cells reconstituted in hNOK mice to clarify the responsiveness of antigen-specific human CD8+ T cells.
We performed a transmission study using mice to clarify the characteristics of the most recent case of scrapie in Japan.
Here, we established outbred FUS/TLS knockout mice to clarify the effects of FUS/TLS dysfunction in vivo.
In this study, we analyzed outbred homozygous FUS/TLS knockout (KO) mice to clarify the effects of FUS/TLS depletion on the central nervous system (CNS) in adults.
To address these questions, we used TLR4−/− mice to clarify the role of TLR4-mediated inflammation in VSMC foam cell formation.
In the present study, we investigated TRI-induced subacute hepatotoxicity in m PPARα, Pparα-null and humanized PPARα (h PPARα) mice to clarify differences in the roles of human and mouse PPARα in TRI toxicity.
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To test whether Fbw7 deletion can induce β cell neogenesis in adult mice, and to clarify the cells that give rise to ectopic β cells, we combined inducible Fbw7 deletion using the R26-CreERT line with lineage tracing using R26-LSL-YFP.
Further studies are needed to understand how mtDNAs containing deletions replicate through the action of normal or mutant Polg or both in the brain subregions of Polg +/D257A mice and to clarify how pathological accumulation of mtDNA deletions cause chronic progression of neuromuscular symptoms of CPEO.
To date E-cadherin has not been directly targeted in the mouse intestine to clarify its role in this tissue.
In intestinal tumorigenesis, Zhang et al. employed several complementary mouse models to clarify the oncogenic function in intestinal tumorigenesis.
We first analyzed the NAD+ content of Deletor mouse muscle, to clarify whether respiratory chain deficiency affected this pool.
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