Suggestions(5)
Exact(6)
We further investigated the ability of mutant mice to acquire fear memory under a less intensive condition.
The ability of 5-HTR4 KO and WT mice to acquire the cued version of the water maze task was then identical, suggesting that the sensori-motor capacities and motivation were not modified in the absence of 5-HTR4.
This task allowed the mice to acquire the procedural aspects of the training.
These structural defects parallel developmental delays in mutant mice to acquire postural reflexes, limb strength and maturation of locomotor memory (Olmstead, 1987).
Importantly, we also found that the chemical cocktail VCR can enable astrocytes of adult mice to acquire neuronal cell properties in vitro (Supplementary information, Figure S2J-S2L), suggestheg the practical implication of such chemical-induced conversion in vivo.
Although the reason for this inconsistency is still unclear, it could point to a species difference: the lifespan of a mouse might simply be too short or the rate of LOH might be too low for heterozygous Brca1 mice to acquire additional mutations necessary for tumour development.
Similar(54)
Finally, while C57BL/6 and 129/Sv mice exhibited comparable behavior during FR1 sessions, C57BL/6 mice tended to acquire food-maintained responding faster than 129/Sv counterparts, and exhibited elevated responding during PR testing.
OSS is dependent on dopamine signaling, as it is altered by the dopamine antagonist cis-flupenthixol, and D1 knockout mice fail to acquire OSS despite being able to acquire food self-administration [19], [28].
The present data combined with our previous finding that dopamine D1 receptor knockout mice fail to acquire OSS [19] suggests that OSS shares neural mechanisms with those mediating psychostimulant self-administration.
HGF knock-out mice failed to acquire normal liver architecture during embryogenesis and suffered from the disintegration of liver parenchyma.
However, after 1 year of age, Nrf2−/− mice begin to acquire autoimmune diseases not seen in their wild-type counterparts.
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