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Glibenclamide, unlike secretin and forskolin, was able to stimulate secretion in Cftrtm1Unc mice, thus indicating that this secretory mechanism was preserved.
The agent indicates high initial penetration into brains (7.23 ± 0.47%ID/g; 5 min) of normal mice, thus indicating a 5-min/120-min 5-min/120-min 5-min/120-mino of 4.7, a brainmark valuptake) clearancet with the ability of agents to tratiose the BBB tofenable PET brain imaging.
Finally, the data show that the lithium's ability to stimulate neurogenesis and cognitive functions was lost in the aged Tg mice, thus indicating that the lithium-induced facilitation of neurogenesis and cognitive functions declines as brain Aβ deposition and pathology increases.
The result showed that in the area of the granulation tissue and in the proliferative area of migrating keratinocytes, a similar number of Ki67-positive cells was observed in both periostin−/− mice and WT mice, thus indicating no significant difference in proliferation (Fig. 5).
Together, these data suggested a loss of astrocyte polarization in 5XFAD mice, thus indicating the detachment of astrocyte end-feet from ECs in AD.
We have found that motor coordination is improved in the RasGrf1 deficient mice, thus indicating that these animals not only live longer but are less prone to frailty.
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Because in mice adoptively transferred GMP can produce myeloid progeny for only a limited period of about four weeks (Akashi et al, 2000), the long-term production of GFP+ BM myeloblasts and the lasting presence of circulating blast in L-GMP-reconstituted mice thus indicated that the transplanted L-GMP had lost their limited capacity to self-renew.
Subsequent crosses showed that the BAC was transmitted to 57.5% (57 of 99) of offspring from this mouse, thus indicating a single integration site.
Furthermore, Northern hybridization analysis of several selected sense-antisense transcripts showed smeary hybridization patterns in the mouse, thus indicating that the transcribed region in the genome may vary and that the cDNA sequences do not always reflect the actual sizes of the transcripts.
This treatment has been found to be beneficial for PH treatment in sickle-Antilles-haemoglobin D mice [ 13], thus indicating the important role of ET-1 in PH in SCD.
This analysis revealed that cPTH increased the expression of RANKL mRNA and lowered that of OPG mRNA in SCs from control mice but not in those from PPRT cells −/− mice (Fig. 3c), thus indicating that one mechanism by which PPR signaling in T cells increases SC osteoclastogenic activity is by regulating their production of osteoclastogenic cytokines.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.
Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com