Exact(1)
And so we turn to another tale of mice, this time traumatised mice.
Similar(57)
We again utilised the Rag-1 mice but this time the mice were ovariectomised.
So they repeated the work with another group of female mice, but this time the untreated septic mice all succumbed to the infection — a seeming paradox.
The study was designed to start therapy of the NZB/W F1 mice at the age of 28 weeks because all mice at this time had positive anti-dsDNA antibody titers and more than 90% of the mice had detectable proteinuria, indicating that autoimmune nephritis was established before the start of treatment in these mice.
Co-inoculation with heat-killed B. bronchiseptica, however, resulted in the accumulation of 8×105 leukocytes and 6×105 neutrophils in the lungs of wild type mice by this time, while the lungs of TLR4-deficient mice contained only 3×105 leukocytes and 4×104 neutrophils (Fig. 6C D).
The histological lung inflammatory response and inflammatory cell influx in BALF in gp91phox−/ mice were similar to p47phox−/− mice, except for a trend towards fewer macrophages in BALF from gp91phox−/ mice at this time point (Figure 3A and B).
In contrast, only female mice had enhanced goblet cell numbers in comparison to naive mice at this time, indicative of IL-13-driven goblet cell hyperplasia (Fig. 1C).
Interestingly, the level of renal Bmp4 mRNA expression in betaglycan+/− mice after this time was not different to that of age-matched wildtype mice.
Due to severe skin premalignant dysplasia from the K14-HPV16 transgeniCstc−/−/− mice after 3 months of age, we were unable to study mice beyond this time point, for compliance with the humane standard of the Animal Research Committee of Harvard Medical School (approved animal protocol number 03759).
IL-17 levels were also elevated in naïve mice at this time (17-fold), but not by as much as in vaccinated mice.
In response to cisplatin, we also observed an increase in CC3-positive cells in KC2 −/− mice that was not observed in KC2 +/+ or KC2 +/− mice at this time point.
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