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In DMF treated mice this increase was not significant.
This pubertal increase in kisspeptin would normally initiate increased GnRH release and thereby lead to activation of the gonads; however, in WT mice, this increase in ARC Kiss1 mRNA is not appreciated.
In sulindac-treated Hif1α ΔIEC mice, this increase was abolished.
While GLUT1 levels were elevated in the left ventricles of GLUT4 null mice, this increase in transcript levels did not reach significance (p = 0.05).
Although methotrexate increased IL-10 levels in the exudates of methotrexate-treated A3 knockout mice, this increase did not achieve statistical significance.
In BALB/c mice, this increase in Tregs induces tolerance to certain cancers and that cytotoxic anti-tumor activity can be restored in vivo via depletion of Tregs (Sharma et al., 2006).
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Research indicates that certain microbes can convert the raw ingredients in the fruit into a molecule called urolithin A. When fed to mice, this increased their lifespan by 45%.
In adult mice this increased cortical area and thickness was achieved through a higher load-induced bone formation at both the periosteal and endocortical surface of Sost KO compared to LC mice (p < 0.001, Fig. 5).
Given that there was no joint swelling in the untreated knees of u-PA-/ mice, this increased swelling seen following the i.a.a
Although fibrin staining varied considerably between mice, a clear increase was observed in Plg −/− mice compared with WT mice, and this increase seemed to be intensified in MMP9 −/−:Plg −/− mice (Fig. 5D,E).
In the marble burying test, we observed a significant increase in anxiety-related marble digging behavior in alcohol-withdrawn mice compared to naive mice, and this increase was prevented by tandospirone pre-treatment (Fig. 1B).
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