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However, when SOX2-deletion cells were transplanted into C57/Bl6 mice they remained tumor free [43].
Almost all meiotic subpopulations of WT-irradiated mice fully recovered at P105, while in KO-irradiated mice they remained about 30% of the non-irradiated level (Supplementary Figure S7c).
However, at 21 d (when inflammation had resolved in control mice), although plasma corticosterone levels had reduced in control mice, they remained elevated in Hsd11b1−/− mice (Hsd11b1−/−, 227 ± 76 n m vs. controls, 86 ± 27 n m).
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Upon extended study of these animals, we observed that the recipient Idua −/− mice appeared quite healthy compared to untreated MPS I mice as they remained unhunched and active in their cages.
Levels of IL-17A, IL-21, and CCL20 mRNA decreased with time in CD25KO mice, whereas they remained at similar levels in γDKO and IFN-γKO mice.
But when Chain injected two mice with it, they remained healthy.
While the Snord116 deletion mice ate more, they remained smaller and leaner, raising questions about differences in energy expenditure.
Once the mice were weaned, they remained on the soy- or casein-based diet until they were euthanized.
As these cells are notoriously reluctant towards in vitro growth, primary cells were passaged through immunocompromised mice, where they remain largely genetically stable.
CYP4A levels decreased from day 11 in both control (Por lox / lox ) as well as HRN mice, after which time they remained slightly higher in HRN mice (results not shown).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com