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Although beta-cell death may contribute to the tumor size difference between WT-βTag mice and PKO-βTag mice these data suggest that cell death differences would tend to lessen the difference between these genotypes.
Thus, consistent with our observation of increased numbers of naïve T cells in non-lymphoid organs of FtDKO mice, these data demonstrated that naïve and central memory CD8 T cells preferentially accumulated in non-lymphoid organs in FtDKO mice.
Taken together with the data showing partial rescue of T cell development after Rhoh-/ cells expressing Myr-ZAP-70 are transferred into Rag2-/ mice, these data suggest that this function of RhoH is physiologically important.
Combined with evidence that YK-4-279 inhibithethe growth of ESFT xenografts in mice, these data provide support for the idea that small molecules that disrupt critical protein-protein interactions involving EWS-FLI1 represent a promising therapeutic approach for patients with high risk disease for whom standard chemotherapy is inadequate.
Combined with our observations following a 4-week insulin treatment in mice, these data collectively suggest the clinical relevance of prolonged increases in insulin.
Together with the premature death of Col1a1 r/r mice, these data indicate that reduced type I collagen catabolism imparts a progeroid phenotype in mice.
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Taken together with our in vivo evaluation in the mouse, these data suggest that pili in general might likely be dispensable for the full virulence of this highly virulent invasive isolate.
Although the sequences are specific to the mouse, these data validate the principle that carefully designed AOs may be used to realize exons 45 55 skipping and, by this means, generate effective amounts of in-frame dystrophin of near-optimal structure in 40 45% of DMD patients.
In conjunction with the previous report of enhanced OC activity in Arf-/ mice [8], these data demonstrate that Arf-/ mice have both increased osteoclastic bone resorption and osteoblastic bone formation which is consistent with increased bone remodeling.
In the same experiment, virus yield from suboptimally-treated mice was reduced approximately 1.6 2.6 log10 compared to placebo-treated mice, and these data are consistent with a previous report in which ACV was administered at a concentration of 0.25 mg/ml [ 10].
Together with the normal phenotype of the knock-in mice [12], these data indicate that the GFP-p65 is functional and the NF-κB regulatory network is physiological.
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