Sentence examples for mice these alterations from inspiring English sources
As far as 3-MH and carnosine levels, since the correction by creatinine value did not greatly affect the result of 3-MH and carnosine levels whose concentrations were greatly differed between cetaceans and mice, these alterations would be due to physiological differences and not due to any artifacts.
Hyperglycemia promotes chromatin remodeling and increased polyploidy levels in hepatocytes from non-obese diabetic (NOD) mice; these alterations are similar, but not identical, to the changes observed in hepatocytes from old mice [ 5].
Although synaptic genes are the most consistently affected functional group, in TASTPM mice, these alterations in gene expression frequently become detectable subsequent to the changes in synaptic transmission and thus effects on synaptic gene expression may be the result, rather than the cause, of the synaptic changes.
However, the fact that Ccl8 and Apod were not expressed in the peripheral leukocyte populations isolated from young and old C57BL/6 mice, suggests that these alterations are likely to be intrinsic to the smooth muscle cells and fibroblasts.
Similar reduction of GAP43 mRNA detection and augmentation of ScMAS staining were observed in cortical extracts from doubly mutant mice, indicating that these alterations could take place in the absence of microglial cell priming by HS oligosaccharides.
Female mice did not show any significant alterations in sniffing in either of the two areas regardless of genotype or treatment, but significant decreases in sniffing in the centre of the arena were seen in both CPO-treated Rl +/+ and vehicle-treated Rl +/− male mice; both of these alterations can be interpreted as slight increases in anxiety.
Specifically, Y2-mediated changes occur consistently throughout the skeleton in these mice, while alterations in leptin levels induce opposing effects on cortical and cancellous bone, as evident in studies involving Y2−/−;ob/ob double mutant mice [9].
Other classes of lipids, such as sphingomyelin, ceramides, cholesterol esters and omega-3 polyunsaturated fatty acids, are altered in the spinal cord of ALS patients and mutant SOD1 mice, although the effects of these alterations in the central nervous system deserve further investigation (18, 19).
This 'loss of function' mutation in the Ank gene increased iPPi concentration while reducing ePPi concentration in (ank/ ank) mouse fibroblasts [ 10], and these alterations were reversed by overexpression of wild-type Ank.
These alterations were rescued in mice after pantethine administration.
Thus, both of these long-lived mice, with alterations in GH and/or IGF-1 action, showed augmented ATF4 levels in liver and heightened ATF4 responsiveness in skin-derived fibroblasts subjected to oxidant or ER stress.
