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Cross-presentation is uniquely inactivated in the ΔY mice thereby allowing the contribution of cross-priming during oral infection to be tested specifically.
Considering these results, we concluded that the experimental design was useful for the identification of odors evoking attraction responses in mice, thereby allowing the discrimination of mice odor preferences.
Finally, the Brucella-susceptible BALB/c mice yielded a larger span between control groups (PBS [150 mM NaCl, 7 mM KH2PO4, 10 mM K2HPO4; pH 6.85]- and Rev 1-inoculated mice) and more homogenous results than CD-1 mice, thereby allowing better statistical evaluations (see Figure S3).
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During studies of the ability of antilymphocyte serum (ALS) to suppress the immune mechanism of mice and thereby allow HeLa cells to grow into a large tumour in the mice, it was observed that many tumours continued to grow even after the ALS treatment had been stopped and full immunological competence of the mice had returned.
In contrast, methylated miRNAs are resistant to periodate oxidation, providing a robust method to reduce the background mouse miRNAs and thereby allowing specific quantitation of the orally administered methylated miRNAs.
The authors of this study overcome this difficulty by using recombinase-mediated cassette exchange (RMCE) to generate an allelic series in mouse embryonic stem cells (mESCs), thereby allowing the quantitative assessment of intrinsic and extrinsic variables that influence FP expression in cells and mice.
The low copy number line of BLG/SV40tsT mice can be crossed with other mice that harbouring either transgenes or gene deletions, thereby allowing the isolation of mammary cell lines from interesting mouse mutants.
MEFs isolated from Shmt1−/− mice were used to eliminate the possibility that endogenous mouse SHMT1 protein could oligomerize with the human SHMT1 fusion proteins thereby allowing nuclear import.
In this chapter, we describe how retrovirus/lentivirus vectors can be used to transfer and stably express genes or small interfering RNAs in mouse and human embryonic stem cells and their progeny, thereby allowing genetic gain‐of‐function or loss‐of‐function analysis and cell lineage selection in a multitude of experimental settings.
When scientists in Kirschner's lab inactivated this protein, the activity of cancer drugs was restored thereby allowing the destruction of pancreatic tumors in mice.
FACS helped to get rid of cellular debris relating to the toxic effects of CCl4 and made it possible to increase the purity up to 99.1%), thereby allowing comparable purity to that of healthy mice.
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