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Whereas chronic HCV infection causes inflammation in patients, in HCV-Tg mice, the host immune reaction against viral proteins is lacking.
While the 96 bp snoRNA sequences are largely conserved between humans and mice, the host gene exons are not [6], [8].
Importantly, in non-ablated newborn mice, the host steady-state engraftment ability was impaired by loss of Gab2 in heterozygous STAT5 mutant background.
Histopathological examination of diseased tissues also showed extensive fungal proliferation and destruction of pulmonary tissue in infected mice; the host response appeared rather limited, in terms of PMN infiltration.
In parabiotic mice, the host liver contains CD49a+ DX5− NK cells of host origin and circulating CD49a−DX5+ NK cells derived from both host and the other parabiont, indicating that the CD49a+ DX5− cells are tissue-resident NK (trNK) cells whereas the CD49a−DX5+ cells are cNK cells.
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BABL/c nude mice as the host were under general anesthesia with 1% pentobarbital at a dose of 5 8 ul/g via intraperitoneal injection.
Ablation of the initial innate response to infection may cause the increased mortality in ASA-treated mice as the host likely succumbs more quickly without the initiation of the "cytokine storm" during acute infection.
For this set of experiments, cells from the same patient were injected into two mice, and the host with higher hIg levels (indicative of higher tumor burden) received PTH treatment, while the other received saline treatment.
The majority of reports of BPI to date involve using mice as the host species.
Finally, we performed reciprocal transplants using p190B+/+Neu and p190B+/-Neu 5-week-old mice as the host to examine the contribution of the heterozygous stroma.
Administration of A2MG enriched (A2MG-E) microparticles following caecal ligation and puncture (CLP) in mice activated the host endogenous pro-resolving pathways and significantly reduced mortality.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com