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In the tests with mice, the higher the dose of PZM21, the more pain relief they felt.
In mice, the higher level of constitutive NO produced by iNOS protects beta-amyloid transgenic mice from developing most typical human symptoms of Alzheimer's disease [18].
Compared with the uninfected mice, the higher overall blood CQ concentrations was likely due to the drug's accumulation within the parasites.
In mice, the higher levels of V2R translate to a greater sensitivity: treatment with the same dose of desmopressin, a synthetic vasopressin agonist, reduces urine production and increases urine osmolarity to a greater extent in females than in males [ 125].
We find evidence of constraint in the lack of trans-eQTL (fewer than would be expected, based on the comparison to adult mice), the higher sequence conservation and the depletion of regulatory gene ontology terms in the cis-eQTLs.
Because hormones had not been administered to these mice, the higher 5αP/3αHP ratio in serum from tumor-bearing mice can reasonably be expected to have resulted from the tumors, which on average had about threefold higher concentrations of 5αP than the respective sera, and >10-fold higher 5αP than 3αHP levels.
Similar(54)
Higher tumour uptakes were found in CA20948 tumour-bearing animals compared to those in H69 tumour-bearing mice with the highest tumour uptake of 19.6 ± 6.6 %IA/g in CA20948 tumour-bearing animals, while for H69 tumour-bearing mice, the highest tumour uptake was found to be 9.8 ± 2.4 %IA/g.
In C57B6 mice, the high-KAA diet increased plasma β-hydroxybutyrate (β-OH-butyrate).
In myostatin-deficient mice, the high-fat diet did not consistently increase hepatic mass (mean+5%, P = 0.4).
In C57BL/6 mice, the high-fat dietary treatment resulted in an increase in IL-2 levels by spleen cells at 48 h T cell activation with levels almost twice as high as those in control mice.
Studies using animals fed high cholesterol diets revealed an increase in amyloid plaque formation in rabbits and in transgenic mouse models of AD [43], [44], [45]; moreover, in these mice, the high cholesterol diet induced cognitive decline [46].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com