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As Dow et al. [ 33, 34] showed also that lipoplexes with DNA encoding IL12 induced a more effective antitumor response than lipoplexes with non-coding plasmid DNA in mice the effect of the DNA-SAINT-18-complex might have potentially enhanced the antitumoral effect of the Interleukins.
In this study, therefore, we examined in mice the effect of the repeated injection of PEGylated liposomes on their pharmacokinetics.
In streptozotocin-induced diabetic mice, the effect of DAMGO was significantly attenuated as compared to that in non-diabetic mice.
Moreover, phosphorylation of p38 MAPK and Foxo1 were upregulated in Akt2/ mice, the effect of which was attenuated by trehalose.
He has found that a 48-hour total fast slowed the growth of five of eight types of cancer in mice, the effect tending to be more pronounced the more fasts the animals undertook.
Interestingly, although type I IFN responses might be affected by Nrf2 in mice, the effect of Nrf2 on STING expression seemed to be restricted to human cells as no alteration of STING was observed in Nrf2/Keap1 knockout murine cells.
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Whereas URB597 did not elicit antiallodynic effects in FAAH mice, the effects of JZL184 were FAAH-independent.
In Purkinje neurones derived from such mice, the effects of etomidate on inhibitory synaptic transmission are greatly reduced.
Since C. elegans is transparent (another advantage over mice), the effects of interfering with the steerins were plain to see.
In mice, the effects was degraded performance on tests of short- and long-term memory.
In comparison with the transcriptional changes found in mice, the effects in primates are generally weaker.
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