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In resin-fed or FXR-null mice, the diminished Fgf15 signal releases the repression on Cyp7a1, leading to higher transcription of Cyp7a1 in livers.
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In Sost KO mice, maturation diminished the bone formation response to loading in the periosteal cortical bone (Ps.BFR/BS: −34%, Ps.MAR: −35%) (p < 0.046, Fig. 5) and therefore the overall bone formation response (MV/BVday0 15: −75% and MS/BSday0 15: −46%) (p < 0.011, Fig. 3).
The transfer of CD4+CD25+ cells harvested and sorted from EAE-malaria mice significantly diminished the evolution of clinical signs of EAE (p<0.01) as compared to animals that were immunized only, or even to the group that received CD4+CD25− cells (Fig. 4F).
The Mecr transgenic mice showed diminished performance in the endurance test, resembling one of the hallmark symptom of patients with dilatative cardiomyopathy [25].
Bypassing the endotrophin-induced EMT in the context of COL6−/− mice diminished the TZDs-mediated beneficial effects on cisplatin therapeutics and resulted in a poor response.
The silver impregnation of the P. murina in the lungs of the treated mice was noticeably diminished in the GMS (Grocott's methenamine silver) stained slides (Panels d-l) while those from the untreated mice exhibited strong silver staining and typical cup-shaped cyst morphology (Panels a c).
Western blotting analysis demonstrated that the protein expressions of Iba1 and CD68 were increased in SOD1G93A mice, and diminished by minocycline administration.
The fact that lordosis induced by exposure to both B6 and BALB/c mice was diminished in the Gαo mutants indicates that, besides ESP1 and Vmn2r116, other pheromones and V2R receptors are probably involved in this behavior because B6 mice do not secrete ESP1 [ 1].
Pes1 expression of tumorspheres originated from MYCN transgenic mice also diminished after the induction of differentiation with growth factors.
For example, the a-wave ratio in the T17M RHO mice was diminished by 33%.
Similar to the described in Fabry disease patients, the sensorimotor assessment of Fabry mice revealed diminished locomotor activity and warm hypoalgesia as assessed in the hot-plate.
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