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In these mice, the decrease in 3α,5α-TH PROG is selectively normalized by the use of fluoxetine in doses that reduce behavioral abnormalities.
In GluN2C KO mice, the decrease in frequency of mEPSCs in layer V pyramidal cells in the mPFC suggests lower excitatory network activity; this finding is also supported by a lower number of vGluT1-positive puncta and reduced dendritic spine density in layer III and V pyramidal cells, both of which reflect the number of glutamatergic synapses to pyramidal cells in this region.
In H3R−/− mice, the decrease in t-MeHA contents at all time points was significant as compared to the basal level.
Moreover, while fibromodulin decreased following AB in WT and CXCR5 −/− mice, the decrease was significantly more pronounced in the CXCR5−/− mice (Fig. 6C).
In MCK-UCP1 mice, the decrease of the SFI was much more pronounced, and recovery was greatly delayed and hardly completed 30 days after lesion (figure 8A).
In myr-Akt1 transgenic mice, the decrease in salivary flow rate is less severe (4 47%) with a significant (p≤0.05) improvement in salivary output at the lower doses of radiation (1 2 Gy).
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In the LGs of DE-induced HIF-1 α CKO mice, the decreases in COX-2 and PGE2 levels may enhance the infiltration of CD3+ and CD11b+ cells.
In Sirt1+/− mice, the decreased SIRT1 concentration is associated with increased apoptosis and fibrosis after UUO (unilateral ureteral obstruction), whereas its activation by treatment with resveratrol or SRT2183 in wild-type mice reduced apoptotic and fibrotic changes in the UUO.
By 12 weeks after the onset of diabetes, the blood flow of plantar skin in diabetic mice decreased significantly compared with that in nondiabetic mice, but the decrease was ameliorated in the limbs treated with MSC-like cells).
In the quantitative analysis, levels of ERα mRNA in mammary carcinoma tissues tended to decrease in mice treated with raloxifene as compared to the control mice, but the decrease was not statistically significant.
In fact, measurement of respiratory parameters in 6-month-old mice confirmed the decrease in RR, TV, MV and SpO2 in DMSXL mice (Table 2).
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