Compared to untreated mice and control MOPC-21 treated mice the clusters of leukocytes were greatly reduced in size and number by treatment of mice for 8 weeks with LTBR-Ig, as illustrated in Figure 1c.
Within 24 h of infusion 5/5 mice administered the cluster 4 O73:H16 bacteria showed signs of toxaemia (cold extremities, reduced appetite, inactivity), one animal had a uterus distended with purulent material and one animal died.
We also have shown that Mtb infection of macrophages in vitro induces foam cell formation, and that inoculation of beads coated with the bacterial cell wall lipid TDM into mice caused the clustering of Adfp-expressing foam cells around the particles.
In mouse tissues the clustering has some similarities to human but also clearly distinct features.
While HOXD/ Hoxd clusters contain similar numbers of antisense loci (three in human and two in mouse), the Hoxc cluster in mouse does not contain any antisense transcripts (indicated by magenta arrows in Figure 5A) where HOXC has five.
In the mouse genome, however, the cluster has considerably expanded [ 11].
If there are no groups, the system can also create a cluster of individuals which can then be revised by selecting the individuals with a mouse and modifying the cluster to which they belong.
Surprisingly, and in contrast to the mouse Mup cluster, the rat genes and pseudogenes are all arranged in a head-to-tail orientation on the reverse strand, there are no associated potential hexapeptide-encoding ORFs and they do not assort into two clearly distinct classes based on sequence similarity or structural arrangement.
A cluster can be selected by moving the mouse over one of the cluster compounds, or over the cluster list on the top left of the screen.
Mouse phenotypes associated with the cluster 2 include "abnormal respiratory alveolar morphology and abnormal lipid homeostasis".
