Sentence examples for mice the bone from inspiring English sources

Interestingly, in humans and mice, the bone phenotype appears just after puberty [18], [19] (our unpublished data).

For RNA preparation from tibias obtained from 1.5 month old N-cadherin transgenic and wild type mice, the bone marrow was flushed out and total RNA was isolated using Trizol (InVitrogen) and cleaned using an RNAeasy minikit (Quiagen, Courtaboeuf, France).

To identify the cause of the reduced splenic B cell compartment in BCS mice, the bone marrow B cell populations were investigated by FACS analysis using a number of antibodies allowing to define the early stages of B cell development.

However, in the normal mice, the bone mineral density and mechanical strength decreased with deteriorated bone microarchitecture after the ovariectomy.

Similarly, compared to wild type mice, the bone matrix of oim mice was more mineralized but displayed a lower average elastic modulus.

81 This bone inhibitory role is supported by the demonstration that, in estrogen-related receptor alpha-null mice, the bone mineral density does not reduce with age.

After sacrificing the mice, the bones were placed in 70% ethanol, then fixed overnight in 4% formalin and embedded undecalcified in methylmetacrylate (Technovit; Heraeus Kulzer, Wehrheim, Germany).

Next, in order to confirm the presence of human RMS cells in the BM of injected mice, the bones were fixed in formalin and stained immunohistochemically, using monoclonal mouse anti-vimentin antibody (clone v9; 1 : 100) (DakoCytomation, Denmark, UK).

However, we also show that ZOL treatment of tumour bearing mice increases the bone volume of mouse leg bones (Figure 7B), which supports previous findings.

Thirdly, in bone marrow chimera mice, the mutant bone marrow shows a remarkable advantage in reconstituting the peritoneal B1a B cells, while displaying a disadvantage in constituting spleen B1a B cell compartment.

Implications and future directions These findings suggest that Terc −/− and Wrn −/−Terc −/− mice recapitulate the bone changes that occur in aging human bones and establish these mice as appropriate models for studying senile osteoporosis.