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In the wild-type mice, the average number of striatal neurons per mm2 was 180±5, and was statistically significantly reduced to 141±4 neurons in the vehicle-treated R6/2 mice (Figure 5A compared to 5B).
Compared to wild type mice, the average percentages of the phenotypic ISP cells were increased by approximately 7 fold whereas the total numbers of these cells were 3 times higher in Hes1 transgenic mice (Fig. 3A).
However, in agreement with the reduced tumor burden of RIP1-Tag2; RIP1-VEGFB mice, the average tumor volume of RIP1-Tag2; Vegfb −/− mice was increased by 81% compared to RIP1-Tag2; Vegfb +/− (33.6±29.9 mm3 vs 18.6±21.3 mm3; Figure 5a, right; p<0.05).
The representative graph shown in figure 2A is relative to weekly measurements of food intake in HFD treated C57Bl6 male mice: the average consumption calculated for these animals is 2.79±0.05 g/mouse/day for WT and 2.69±0.04 g/mouse for ctsk−/− mice).
In the lesioned mice, the average length of REM sleep bouts did not change at night compared to HCRT-ko mice given saline, but the average length of the non-REM (F1, 26 = 12.35, P = 0.002) and wake bouts (F1, 26 = 4.623, P = 0.041) significantly decreased during the night, which explains why the night time percentages of non-REM and wake were unchanged (Table-1).
In control mice the average age at which palpable tumors were first detected was 95 days.
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For each mouse the average proportion of labeled neuronal profiles was calculated.
Under these conditions, tissue copper concentrations were significantly greater in control mice, 502 (406-597) μmol/kg dried-defatted tissue, than in ob/ob mice, 339 (316-361); the average ratio in copper concentrations between control and ob/ob mice was 1.5 (P = 0.0053).
A significant decrease in body weight was observed in male Tg mice, whereas the average weight of female Tg mice was not reduced significantly compared with WT controls.
In contrast, focal areas of necrosis were present in 4 of 6 CCR2−/− → CCR2−/− mice and 2 of 7 CCR2−/− → WT mice with the average area of necrosis being 0.7 ± 0.3 and 1.1 ± 1.0% of the area of regeneration/residual necrosis, respectively.
After intraperitoneal injection, strain Eg-101 killed all suckling mice but a <10% of adult mice; RabV strains 97-103 and 99-222 killed approximately one third of suckling mice, and the average survival time was 11 days (range 10 14 days).
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