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To test this in Atxn2 ko mice, the ability to induce LTP was measured in slices from the hippocampus and the amygdala.
These data demonstrate that while the main rhythm parameters of extra-SCN circadian oscillations are maintained in Vipr2−/− mice, the ability of these oscillators to resist phase shifts is compromised.
While we found compensatory changes in the AE3−/− knockout mice, the ability to maintain acid base balance in the inner retina is likely to remain dramatically compromised given the phenotype of these mice.
In control mice, the ability to re-localize into intra-abdominal lymphoid organs increased after several rounds of division, in parallel with the acquisition of tissue specific homing molecules such as the beta7 integrin chain, and the alpha4-beta7 integrin heterodimer.
However, we must point out that comparing other tissues of p53+/+ and p53−/− mice, the ability of p53 to repress SIRT1-ΔExon8 mRNA expression displayed some tissue specificity, with no effect of p53 knockout on SIRT1-ΔExon8 levidentvinent in mouse spleen and heart tissues (Figures 7D and 7E).
In mice, the ability to regenerate wounded cartilage is a heritable trait [ 44].
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When 1-MT was added to unfractionated spleen cell culture of NP-mice, the ability of 4-1BB ligatoon to reduce Ag85B-induced IFN-γ secretion was unchanged (Fig. 5 E).
Previous research has shown that muscles from old mice regain the ability to doctor themselves when transplanted into young mice.
Initial experiments comparing diet-induced obese (DIO) vs lean mice confirmed the ability of this assay to reveal the relative insulin resistance of DIO mice relative to lean controls.
Published studies have shown that mouse TIGAR can also be responsive to p53's transcriptional activity and p53-deficient mice lose the ability to induce TIGAR expression following myocardial injury.
We then evaluated if gliomas induced by PDGF-B overexpression in NG2-KO mice maintain the ability to propagate as tumors after in vivo transplantation, as is typical of those from wild type mice [ 25].
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