Sentence examples for mice that specifically from inspiring English sources

Next, we demonstrate the utility of this recombination system by using it to target cre to the 3′ end of the mouse neuron-specific enolase (Eno2) gene carried on a 250-kb BAC, which made it possible to generate BAC transgenic mice that specifically express Cre in all mature neurons.

Further, the ESAM high DC population identified by Lewis et al., whose development depended on canonical Notch2-RBP-J signaling, was required for optimal T cell priming (Lewis et al., 2011), as evidence by decreased T cell proliferation in the spleens of RBP-J-deficient mice that specifically lacked the ESAM high subset.

Here we report on the characterization of Vp16-Jazz-transgenic mice that specifically over-express the utrophin gene at the muscular level.

An important technical development in the study of adult neurogenesis is the generation of transgenic mice that specifically express fluorescent proteins in newborn dentate granule cells.

Monocyte numbers, as well as inflammatory macrophages recruited to the peritoneal cavity, were reduced in transgenic mice that specifically over-expressed Slfn4, while macrophage numbers and hematopoietic activity were increased in the livers and spleens.

To determine if Cthrc1 is sufficient to increase bone mass, we next generated transgenic mice that specifically overexpressed 3×HA tagged Cthrc1 in osteoblasts under the control of the Col1a1 2.3 kb osteoblast-specific promoter (Figure 3A).

An exception is a transgenic mouse that specifically overexpresses BMP4 under control of the neuron-specific enolase (Nse) promoter.

Moreover those experiments were not performed in mice that were specifically defective in IgG3 subclass antibodies in MRL/lpr background.

The generation of mice that were specifically deleted only for neuronal FTO had a similar phenotype of growth retardation as the whole body FTO deletion, suggesting that a major function of FTO occurs in the brain.

Using transgenic mice that lacked specifically D2-subtype autoreceptors on dopamine neurons, but expressed postsynaptic D2 receptors on nondopaminergic neurons, Bello et al. recorded the activity of presumed midbrain dopamine neurons in horizontal brain slices.

In order to verify these hypotheses, this study presents an inducible transgenic mouse model that specifically expresses the most common LMNA c.1824C>T HGPS mutation in neurons as well as in cells of bone, skin and heart.