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Villeda had conducted pilot studies with pairs of surgically conjoined mice that shared a blood supply for several weeks.
In our study, four to seven weeks of exposure to sucrose post-weaning altered adult sucrose-seeking and weight gain among mice that shared an identical "thrifty genotype" and were exposed to identical environments as adults.
Specifically, there was no deficit when only one MUP haplotype was shared, but there were many fewer matings between mice that shared both MUP haplotypes (complete match) than expected under random mating conditions (Table 1: model 4, p < 0.002).
We found no evidence for disassortative mating on the basis of MHC haplotype sharing (Table 1: model 2), i.e., there was no evidence for fewer successful matings between mice that shared either one or both MHC haplotypes relative to those that shared no haplotypes (Table S2; Figure S1).
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To define duplicated genes, we initially determined the best human hit for each mouse gene, and formed families of mouse genes that shared the human ortholog.
In a previous murine genetic model of GCP, TGF beta 1+/− mice developed glandular hyperplastic lesions that shared morphologic features with human GCP, with mixed inflammatory infiltration of the surrounding mucosa and chronic vasculitis in the tissues adjacent to these lesions [41].
Rather, short-term TPA treatment exacerbated atopic dermatitis in EPI−/− mice, resulting in a phenotype that shared key hallmarks of the acute phase of the disease in humans (Bieber, 2010).
These include Eurexpress (8) a transcriptome-wide mouse gene expression study that shares the same anatomy ontology.
There have been recent efforts to standardize gut microbiota experiments, for example by establishing standardized microbiota in isobiotic mice that would be shared by institutions involved in gut microbiota research (Hooper et al., 2012).
Furthermore, microarray expression profiling studies defined a gene expression signature of MYC-induced prostate cancer in Hi-MYC mice that shares a number of features with human prostate cancer [1], [45].
It was firstly demonstrated in a parabiotic pairing of young and old mice that share their circulatory system.
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