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When blood stage infections were analysed in mice that resulted from infections initiated with 1×103 sporozoites we calculated that the luminescence signal measured at 48 h was the result of only 1 5 schizonts.
We then mated Wwoxflox/flox mice with homozygous EIIA-Cre transgenic mice that resulted in the first familial generation (F1) of pups having one Wwox allele with wild-type sequences and one Wwox allele with Exon 1 deleted (Wwox+/ΔCre).
A follow-up study [ 40] used mice that resulted from crossing SOD1G93A and VEGF δ / δ models [ 199].
First, we performed a FACS analysis of xenograft tumor tissues in nude mice that resulted from the injection of bulk Li-7 cells.
Exposure delivered 127±68 M. tuberculosis Erdman bacilli to the lungs (N=97 DO mice) that resulted in complete data from 70 individual DO mice to train machine learning models.
Recently, we described a p.Tyr64His mutation in the developing enamel extracellular matrix (ECM) protein amelogenin in mice that resulted in eruption of malformed tooth enamel that exhibited severely compromised mechanical properties thereby mirroring human amelogenesis imperfecta (AI) (9).
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The previous development of hUGT1 mice offered us the opportunity to examine activation of the UGT1A1 gene since chemicals or agents administered to neonatal hUGT1 mice that result in the reduction of TSB levels are directly inducing UGT1A1 expression20,23,33,42,43.
We generated a Dlc1 gt mouse that resulted in hympomorphic expression of the 6.1 Kb transcript and the 123 KDa Dlc1 protein.
Additionally, an in vivo bone forming potency assay was used in an ectopic mice model that resulted in compelling bone formation (11.6 ± 3.1% and 12.8 ± 3.3% for the bioreactor and control tissue culture flask condition, respectively).
We defined essential genes (n = 2366) as previously described [ 4], by retrieving a list of human orthologs of mouse genes that resulted in lethal phenotype in embryonic and postnatal stages upon knockout as catalogued in Mouse Genome database [ 20].
Briefly, a list of human orthologs of mouse genes that resulted in a lethal phenotype in embryonic and postnatal stages upon knockout was obtained from the Mouse Genome database [18].
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