Sentence examples for mice that models from inspiring English sources
We show that a haploinsufficient deletion in mice that models loss of a human 7q22 CDS causes hematopoietic abnormalities that include a myeloid lineage output bias, impaired lymphoid repopulating potential, and a pronounced age-associated expansion of HSC and MPs.
While a previous study showed that intranasally administered S. pneumoniae (D39 strain) produced intrapleural injury in CD1 mice, that model was characterized by early mortality that restricted analyses to the acute setting; over 48 h [11].
These observations provide a mechanistic basis for basement membrane fragility that leads to epidermal blistering in FS-spectrum diseases and in the blebs mutant mice that model them.
This intervention study presents evidence, for the first time, that restoration of ascorbate from adequate to optimal physiological levels reduced tumor growth rates and moderated HIF-1 pathway activity in a mouse that models the human ascorbate dependency condition.
Such behaviors are also known to increase in mice that are models for obsessive compulsive disorder [ 17– 17].
The SCT model offers promise for further mechanistic understanding of the differences among XXY, XYY, and XY mice that may model differences in humans with similar genotypes.
Polyps in PJS patients and in Lkb1+/− mice that model PJS polyposis are frequently characterized by elevated cyclooxygenase-2 (COX-2).
Led by Youngchul Sung, the team engineered a strand of DNA containing two genes from TB and injected it into mice that model chronically sick patients.
Wang went on to probe the mechanisms behind these cardiac abnormalities, striking up a collaboration with Jeffrey Esko, a biologist at UC San Diego who had engineered mice that model MPS.
We used a γ-secretase inhibitor to lower β-amyloid levels in young mice that model DS.
These features closely resembled degenerating hippocampal neurons in our mice that model hippocampal sclerosis by inducible expression of p25, the truncated activator of cdk5 [28].
