This has been shown by the work of Hanahan and Folkman, who have followed tumor development in transgenic mice that develop pancreatic islet tumors.
To determine how the treatment curbed tumor growth, the researchers tested genetically engineered mice that develop PDA.
The rather short incubation time achieved by Ki-ChM mice suggests new approaches to produce mice that develop prion disease with very short incubation periods.
In addition, the amount of F-actin associated with nephrin is increased in Robo2 knockout mice that develop an altered podocyte foot process structure.
Ghadiri and his Scripps colleagues have now tested their compound in mice that develop artery clogging plaques when fed a Western-style high-fat diet.
Researchers have had difficulty testing the roles of plaques and tangles because no one had created mice that develop both--until last year, when neuroscientist Frank LaFerla of the University of California, Irvine, and colleagues engineered mice that develop plaques and tangles in the same brain regions as the brains of people with Alzheimer's disease do.
PC mice were hosts for the K8484 tumour and were the non-tumour-bearing cage mates of mice that develop KPC tumours; PC mice lack the KRAS mutation present in the KPC mice and hence do not develop tumours.
Within this series, there is often an allelic combination that yields liveborn mice that develop overt phenotypes as they age, and that can be used to study the physiological relevance of the protein.
Several labs have bred transgenic mice that develop plaques, and although they don't develop the widespread neuron death and severe dementia seen in patients, they are used as models for research.
More recently, transgenic mice were developed which overexpressed mutant tau by 7 13 fold, resulting in mice that develop a tauopathy associated with neurodegeneration and impaired cognition [25].
We were interested in determining how anti-dsDNA antibodies could arise in mice that develop anti-EBNA-1 antibodies upon exposure to EBNA-1 protein.
