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Over the past decade severely immune-compromised mice that allow better engraftment of human tissues (such as thymus, liver, bone marrow, and stem cells) have been developed.
Since Smyd2 expression is not restricted to the heart (Fig. 1C), we generated mice that allow the tissue specific deletion of Smyd2 expression.
We applied Cre/loxP system to generate conditional gene targeted mice that allow inactivation of critical components of Notch signaling pathway in the skin.
Instead of generating p53 germline mutations, we generated mice that allow global somatic deletion of one or both copies p53 at any chosen time.
Therefore, we investigated the development of retinal vasculature by using Sca1-GFP transgenic mice that allow the direct visualization of GFP-positive vascular endothelial cells [11], [12], [13].
To evaluate whether hESC-ECs are capable of forming functional blood vessels in vivo, we used Matrigel plug and tissue-engineered vessel models in immunodeficient SCID mice that allow dynamic and long-term observation of blood vessels derived from implanted cells [8], [17].
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Here, we propose a novel and inexpensive system for measuring electroencephalographic signals and other biopotentials in mice that allows for natural movement.
The research team led by Cheng and Nusse used a strain of laboratory mice that allowed the scientists to track the activation of a cell-signaling pathway driven by a protein called Wnt.
Together, these data argue for plasticity in the genetic program of peripheral DNCD3 cells from young NOD mice that allows them to differentiate in an extra-thymic environment into mature T-cells with regulatory (anti-diabetogenic) function.
In this report, we used features of the engineered mice that allowed control of timing of NPC rescue.
In this study, the authors only found slight modifications of single-channel activity in Ser2808-mutated mice that allowed for normal Ca2+ transients and unaltered overall cellular function.
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