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Likewise, a role of FTO in the regulation of gene expression is more fitting with the phenotypes of Fto mutnat mice than a role in DNA repair.
Repeat dosing at 3- or 7-day intervals produced greater induction of TNF- α and growth delay in colon 38 tumours in mice than a single dose of DMXAA (Philpott et al, 1995).
This is supported by a recent follow-up study, in which Dheenadhayalan and coworkers [ 40] demonstrated that expression of the complete PE_PGRS33 protein in the non-pathogenic fast-growing M. smegmatis, causes the strain to survive better in infected macrophage cultures and mice than a parental strain or a strain expressing only the PE domain of the protein.
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Strikingly, fasting plasma Chol levels were lower in Ad-si23 mice than in Ad-ctrl mice.
These tumors arose at a higher frequency in Ntv-a mice than in Gtv-a mice, suggesting that specific populations of cells respond differently to a particular Oncogene.
An early study revealed that a strain (R265) of the predominant subtype in the outbreak (VGIIa), was more virulent for A/Jcr mice than an isolate (R272) of the minor subtype (VGIIb), the proposed parental strain of R265 [15].
This very low dose 5-AZA-CdR was much more effective in prolongation of the survival time of the leukemic mice than an intense dose of ARA-C (75 mg/kg per day intraperitoneally for five days).
While I'd much rather come across a mouse than a snake, I'm not sure I wouldn't prefer the snake to 2,000 mice, particularly if I'm trying to grow a supper that isn't mouse.
As Zuk notes, "A monkey is a lot more like a mouse than a grasshopper is like a flea".
This wasn't because their peers were avoiding them; the healthy rodents were no less likely to enter a nest containing a sick mouse than a healthy one.
She is dainty and quick to smile, with a voice that sounds more like a mouse than a lion.
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