Sentence examples for mice targeted for from inspiring English sources

Chimeric mice targeted for both alleles of fukutin develop severe muscular dystrophy; however, these mice do not have proteinuria.

Furthermore, we recently demonstrated that no tumors develop spontaneously in mice targeted for conditional deletion of Wwox in the mammary gland [ 15].

Therefore the unexpected differences between mice targeted for c-IAP1 and c-IAP2 might potentially have occurred due to differences in the ES lines used for their construction.

In the present study, we examined the genetic loci of mice targeted for the closely linked c-IAP (cellular inhibitor of apoptosis) genes, which were generated in 129 ES cells, and found that, despite extensive backcrossing into a C57BL/6 background, c-IAP1−/− animals are also deficient in caspase 11.

Since the gene for caspase 12 (Casp12) is in close proximity to that of caspase 11 on mouse chromosome 9, it might be helpful to test mice experimentally targeted for caspase 12 constructed using a 129-derived ES cell line for the caspase 11 mutation [ 26].

After preliminary studies established the onset of disease between 10 and 12 weeks of age, 6- to 8-week-old male W/BF1 mice were targeted for transplantation with either T-cell-depleted bone marrow or purified hematopoietic stem cells from haploidentical B6C3/F1 mice.

To further validate whether OXT may act indirectly to enhance intrinsic excitability of hippocampal interneurons through activation of CA3 OXTR+ pyramidal neurons, CA3 OXTR− interneurons in slices from Oxtr Venus-Neo/+ mice were targeted for recording, filled with biocytin to allow post hoc reconstruction (Supplementary Fig. 6a).

However, thanks to a unique mouse model targeted for the ERα palmitoylation site membrane, we recently demonstrated a very contrasted involvement of MISS-mediated E2 action in two different tissues: the uterus in which the E2 response depends on ERα nuclear action and the arteries involving exclusively MISS of ERα to mediate E2 response (Abot et al, 2013; Adlanmerini et al, 2014).

For instance, in mice, targeting CD11bhigh DC using DCIR2 [29], Dectin-1 [30] or CIRE/mDC-Sign [31] induced CD4 responses whereas targeting CD8αpos spleen DC using anti-DEC-205 [29] or Clec9A [31] induced CD8 responses.

To circumvent the embryonic lethality of the DG knock-out mouse, highly chimaeric mice, generated with ES cells targeted for both DAG1 alleles, were generated [ 34].

We verified that the mouse targets for the most GC-rich human genes are much less GC-rich by an average of 6.9% (e.g., a human target that is 60% GC would only be 53% GC in the mouse).