Conversely AKR mice sustain a chronic Trichuris infection, respond with a TH1 immune response (IFNγ, IL12), and subsequent establishment of colitis [ 8].
p27 knock-out mice sustain a variety of abnormalities including increased body size, multiple organ hyperplasia, pituitary tumour, and sterility due to underdeveloped ovaries (Nakayama et al, 1996).
Upon activation of PPARβ/δ, transgenic mice sustain an inflammatory skin disease strikingly similar to psoriasis, featuring hyperproliferation of keratinocytes, dendritic cell accumulation, and endothelial activation.
These findings correlate with a previous study in which mIL-8Rh knockout (KO) mice sustained higher renal bacterial burdens than did wild-type mice and eventually developed fibrosis and renal scarring (Hang et al., 2000).
A growing collective of TFs are involved in achieving intestinal crypt homeostasis and previously we have specifically shown a role of Myb, exploiting several Myb hypomorphic mutant mice, sustained survival of which allowed the analysis of adult tissues not possible with embryonically lethal MybKO mice and that complemented the inducible intestinal-specific MybKO studies.
Following intravenous luciferase vector administration to neonatal mice, LTR1 sustained a higher level of liver transgene expression than an equivalent dose of a standard lentivirus.
CD40 engagement of CD4hi T cells from both NOD and BALB/c mice sustained the association of CD40 with the raft fraction (Fig. 4B).
TLR4-deficient mice sustained smaller infarctions and exhibited less inflammation compared to wild type mice after myocardial ischemia-reperfusion injury induced by 1 hour of coronary ligation followed by 24 hours of reperfusion [38].
Thus, the cD3KO mice sustained specific postnatal D3 depletion specifically in Pax7-positive cells.
In mice, sustained activation (by high fat feeding) of mTOR is associated with hepatic insulin resistance [ 45].
