Sentence examples for mice supporting a from inspiring English sources

Additionally, lifelong overexpression of Nampt preserved muscle NAD levels and exercise capacity in aged mice, supporting a critical role for tissue-autonomous NAD homeostasis in maintaining muscle mass and function.

Increased expression of genes involved in cell cycle regulation and DNA replication is characteristic and specific for the early stage in Pmp22−/− mice, supporting a primary function of PMP22 in the regulation of Schwann cell proliferation.

Low dose LPS studies in mice whose TLR4 is solely expressed on their endothelial cells demonstrated patterns of P-selectin induction (endothelial cell activation) and neutrophilic sequestration in the lungs similar to those observed in TLR4 wild-type mice supporting a role of endothelial cell TLR4 in the host inflammatory response47.

Lastly, we found reduced RGC numbers in Nf1+/−GFAPCKO mice, supporting a model in which the combination of optic nerve Nf1 heterozygosity and glial cell Nf1 loss results in disrupted axonal-glial relationships, subsequently culminating in the degeneration of optic nerve axons and loss of their parent RGC neurons.

While we could not systematically delineate gradual arrests using our top-mounted cameras, we observed unambiguous abrupt arrests (see supplemental videos) in DKO mice supporting a role for OX1Rs in suppressing these events.

In eight weeks old adult mice, we observed similarly shortened growth plates in Smad1cKO/cKO and Smad1cKO/cKO Smad5+/− mice supporting a continued postnatal requirement in postnatal growth plates (Figure 1D F).

Moreover, ∼94% of the predicted piRNA target sites were absent at the 5′ ends of mRNA fragments in the 5′ RACE library from Miwi−/ ADH mice, supporting an essential role of MIWI slicer activity in generating mRNA fragments cleaved at such piRNA target sites.

Like in narcoleptic canines, our findings in DKO mice support a role for cholinergic systems in promoting cataplexy.

This fact, together with the hair abnormalities seen in NDUFS4 knockout mice, supports a role for RCCI deficiency in the hair abnormalities of Hq mice.

DDAH-1 transcription in liver has been proposed to be regulated by FXR [25]; our finding that FXR expression is modified during liver regeneration and is significantly higher in TR KO mice supports a role for this nuclear receptor.

While 16.6% of the aged mice were able to support a parasitemia lasting more than 12 days, none of the young mice supported a parasitemia lasting this long, and average length of parasitemia for old vs young was 7.1 vs 3.9 days respectively.