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Studies with FcγR-deficient mice support the critical role of the different FcγR in the in vivo functional effects of therapeutic monoclonal antibodies.
Our VEGFR imaging and immunohistochemical results comparing diabetic and non-diabetic ApoE−/− mice support the emerging role of VEGFR as a biomarker for assessing complex and inflamed atherosclerotic plaques.
Adult IFNAR mice support the in vivo growth of BTV-4 after intravenous inoculation.
Genetic analysis of agrin and MuSK deficient mice support the common function in AChR clustering [24], [25].
Numerous studies based on single mutant mice support the notion that MSH2/MSH6 is the major MutS complex involved in CSR and SHM.
Taken together, the results obtained in Ceacam1−/− mice support the view that a main function of CEACAM1 expressed by lymphocytes is to regulate their proliferation.
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Results of in vivo, ciliotoxicity and gamma scintigraphy studies on mice supported the above inference.
Mice deficient in ST2, the receptor for IL-33, recapitulated the results seen in MyD88-/ mice, supporting the role of IL-33 as a mediator of Th2 responses.
Subcutaneous injection of asbestos-treated, but tumor-free mice with syngeneic mesothelioma tumor cells resulted in a significantly higher incidence of tumor growth when compared to naïve mice supporting the role of the environment in tumor progression.
A recent study has also demonstrated that multiplex gene editing to confer leukemic drivers in healthy human HSPCs is insufficient for the development of leukemia after transplantation in mice, supporting the need for a dysplastic stroma in disease initiation.
Conditional Sox2 deletion in pre-existing skin papilloma and SCC leads to tumour regression and decreases the ability of cancer cells to be propagated upon transplantation into immunodeficient mice, supporting the essential role of SOX2 in regulating CSC functions.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com