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A heterozygous breeding colony of mice with a null allele of lmna [14] was established to obtain lmna−/−, lmna−/+ and lmna+/+ (wild-type), from mice supplied by Carlos Lopez-Otin (University of Oviedo, Spain).
Nrf2 KO mice supplied by RIKEN BioResource Center (Tsukuba, Japan) were bred and maintained.
Col2a1-CreER T2 ; Ihhfl/fl mice (supplied by BL) were bred as previously described [ 6].
Macrophages were prepared from adult, male C57BL/6 mice (supplied by Harlan, UK), as described previously [ 45].
Five-week-old female C57BL/6 mice (supplied by Japan SLC, Inc., Hamamatsu, Japan) were used in all experiments.
Nine-week-old female BALB/c athymic nude mice (supplied by Japan SLC, Inc., Hamamatsu, Japan) were used in all experiments.
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CD-1 strain mice were supplied by Vital River Laboratory Animal Technology Co. Ltd. (SCXK(Jing)2006-2009, Beijing, China).
Female BALB/c-nu/nu mice were supplied by the Medical Experimental Animal Center of Guangdong Province (Guangdong, China).
Eight-week-old male BALB/c athymic nude mice were supplied by Japan SLC, Inc. (Hamamatsu, Japan) and used in all experiments.
The C17.2 cell line adopted from the cerebellum of newborn mice was supplied by Dr. Evan Y. Snyder from Harvard Medical School, Boston, MA.
ROSA26 lacZ mice were supplied by Dr Annemieke IJpenberg, MRC Human Genetics Unit, Edinburgh.
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