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Specifically, mdx 3cv mice still express ~5% of a near-full-length dystrophin protein (Cox et al., 1993b; Li et al., 2008).
Some (but not all) lines of loss of function WWOX mutant mice have higher incidence of tumours, however tumours from heterozygous mutant mice still express WWOX (19– 23).
Although mice homozygous for two Tln2 gene trap alleles [2,13] or a Tln2ko allele [12] are viable and fertile, it is now apparent that these mice still express talin2 protein in several tissues.
Interestingly, no abnormality has been reported for the heterozygous Lmnb1 knock out mice (Stewart et al., 2007; Coffinier et al., 2011), and it is estimated that these heterozygous mice still express 70% of lamin b1 (SG Young, personal communication).
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We also verified that Cnr2 −/− mice still expressed CB1 receptors, using the following primers: mouse Cnr1: sense 5'-CTCCTGGCACCTCTTTCTCAG-3', antisense 5'-GTCTCCTGCTGGAACCAACGG-3'.
Moreover, M83+/−- and M20+/−-mice still express endogenous mouse alpha-synuclein, which could contribute to the changes observed in those mice considering that prion-like propagation of alpha-synuclein aggregates can be induced in wild-type mice [ 28, 31].
Even though no evidence supports a direct role of RPGRIP1 in the subcellular targeting of opsins, two prior studies reported the mislocalization of rhodopsin in Rpgrip1 tmiceli mice, which still expresses RPGRIP1, but without its C2 and RID domains, and Rpgrip1 nmice7 mice, which lack RPGRIP1 expression.
The researchers could detect when Arc was turned on in the visual cortex over the course of several days, and they could also get clues about Arc's function by looking for differences between the mice that still expressed Arc and those that didn't.
CD4+ T cells in apigenin-treated mice were still expressing low levels of COX-2.
While the CpG island in intron 10 of KCNQ1 and promoter elements could not be detected, the antisense transcript KCNQ1OT1 that regulates CDKN1C imprinting in human and mouse is still expressed.
Perivascular nestin+ cells in bone marrow of Lrp6 +/− and Lrp6 −/− mice, however, lost LRP6 expression, even though other types of cells in bone marrow still express LRP6 in these mice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com