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However, Tregs from CTLA-4 knockout mice still display normal suppressive function in vitro [41].
SMNΔ7 SMA mice still display a considerably severe phenotype and die on average at two weeks of age.
Although STAT6 signaling is widely accepted to be crucial in Th2 polarization, studies demonstrating that STAT6−/− mice still display Th2 responses 17, 42 suggest that STAT6-independent mechanisms involved in Th2 polarization also exist.
Furthermore, Chao et al (2010) have validated that the primary tumours formed by mesenchymal-like MDA-MB-231 breast cancer cells in immunocompromised mice still display a mesenchymal phenotype but not a more epithelial phenotype in both the central and peripheral areas of the tumours, which was consistent with expression pattern in vitro of MDA-MB-231 cells.
Of note, TLR2 KO mice still display an induction of cytokines and chemokines when infected with pneumolysin-deficient S. pneumoniae, suggesting that other pattern recognition receptors contribute to this response, In this respect, the recent finding that TLR9 can recognize pneumococcall DNA is of relevance (Mogensen et al., 2006).
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Two-thirds of the live-born KI mice survived the weaning period, with subsequent improvements in their growth and motor functions; however, these mice still displayed cardiovascular dysfunction and behavioral problems due to serotonin deficiencies.
At day 42 p.i., Ceacam1−/− mice still displayed increased splenomegaly.
In the mdx∶utrophin mutant chimeras, although iPSC-dystrophin was also supplied to the muscle sarcolemma, mice still displayed poor skeletal muscle histopathology, and negligible levels of dystrobrevin in dystrophin- and utrophin-negative areas.
When Wsf1 was deleted only from pyramidal neurons in the mPFC, the mice still displayed stress-induced depressive behaviors.
V1 IN-ablated mice still displayed marked deficits in their gait, including a persistent hyperflexion of the hindlimbs during walking, which was particularly prominent in the mid-swing and early stance phases of the step cycle.
Fenofibrate-treated mice still displayed a significantly increased survival rate compared to controls receiving a standard diet, even when being inoculated with a 10-fold higher dose of S. typhimurium (500 CFU, Fig 1B).
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