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These mice start to develop tau pathology around 9 months of age.
Normal mice start to lose this fear response after about 2 days.
NOD mice start to form SG infiltrates from 8 weeks of age.
N1N2K5 mice start to lose hair as soon as 1 week post tamoxifen injection and show complete and irreversible hair loss after 1 month (Figure 1A).
NEP-deficient mice start to become obese under a normocaloric diet in an age of 6 7 months and thus are an ideal model for the typical human late-onset obesity.
MPSIIIB mice start to retain urine at 4 6 months of age (not shown), often leading to hydronephrosis or uremia, which may reflect autonomic control of urinary sphincter function or more likely, blockage of the urinary tract [30].
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Soon headless mice started to appear.
Some mice started to develop tumors around week 6.
Independent of the virus dose used, LASSARAB or BNSP333 suckling mice started to succumb to the infection by day 7.
Following 2 weeks of diet feeding, a cohort of mice started to receive the CYP2E1 inhibitor diallyl sulfide (100 mg/kg/d, i.p).
Despite this severity of infection, all the ECTVIFNα/βBPGAGmut infected mice started to recover from disease and increased bodyweight from 16 dpi (Fig. 4 and Supplementary Figure 3).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com