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When he treated the mice simultaneously with radiation and with a drug that interferes with DNA repair, however, the stem cells no longer had an advantage.
To assess whether immunizing Apobtm2SgyLdlrtm1Her J mice simultaneously with different atherosclerosis-related epitopes engineered in a single recombinant protein is effective in reducing atherosclerotic lesions.
After 16 hours, B16 melanoma cells (1 × 10 cells/mouse) were i.v. transferred to the tail veins of DT-treated CD11c-DTR Tg mice simultaneously with either total DCs or NKDC-depleted DCs (1.5 × 10 cells/mouse) prepared from WT mice.
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The characterization and semi-quantitative assessment of the infecting T. cruzi population by LSSP-PCR in different organs of mice simultaneously infected with both JG and Col1.7G2 were used to analyze infection and tropism.
Naive mice simultaneously injected with the same tumour cell suspension developed tumours within 21 days as expected.
Specific and non-specific targeting was examined in nude mice simultaneously grafted with PLAP-positive tumours derived from MO4 1-4 cells, and CEA-positive tumours, derived from 5583-S cells.
Furthermore, the reduction of CD11b+Gr-1+ MDSCs in spleens was more significant in mice simultaneously treated with anti-CAF therapy and the DC-based vaccine than in mice treated with anti-CAF therapy alone (P = 0.0073).
Corresponding to IFN-γ production by CD8+ T cells in the spleens, cytotoxic effects against E.G7 tumor cells were enhanced more significantly in mice simultaneously treated with anti-CAF therapy and the DC-based vaccine than in mice treated with the DC-based vaccine alone (P < 0.001) (Fig. 4a).
In two more recent studies [ 14, 23] a commercially-available PET/CT device equipped with PSF reconstruction was used to image several mice simultaneously.
Furthermore, the system could generate multiple Tg mice simultaneously.
SCID mice treated simultaneously with LAB027 and oxaliplatin had significantly smaller tumors than untreated mice at day 27 (−78%, P<0.001).
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