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ALA administered to 5/6Nx mice significantly improved the muscle strength with the standard dose (Fig. 2E).
It was first shown in 2016 by Zhou and Silva, who found that removing the gene from mice significantly improved their memory.
Intramuscular injection of AAV-Nano-Dysferlin in young dysferlin-deficient mice significantly improved muscle integrity and decreased muscle turnover 3 weeks after treatment, as determined by Evans blue dye uptake and central nucleated fibers, respectively.
WT-vehicle mice significantly improved performance in subsequent IDS as compared with the reversal (P<0.05).
Importantly, upon AMG386 treatment, the overall survival of GL261‐bearing mice significantly improved (Fig 4I, median survival 24 days).
Transplantation of BMSCs to CCl4-treated mice significantly improved not only liver function, but also liver fibrosis.
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We have previously shown that chronic administration of the HDAC inhibitor SAHA to R6/2 mice significantly improves some motor and neuropathological phenotypes [23].
We reported previously that intravenous administration of P140 to MRL/lpr mice significantly improves their clinical and biological manifestations and prolongs their survival.
For instance, simulated microgravity was applied to bone marrow stromal cells for transplantation in contusion model mice, significantly improving motor function [ 27].
Indeed, preventing the accumulation of senescent cells in aging mice significantly improves healthspan, demonstrating that cellular senescence, regardless of its induction, is a cause of aging associated disorders (Baker et al, 2011).
However, unlike the impaired neurogenesis observed in GFAP/Gp120 Tg mice and Faah−/− mice, these GFAP/Gp120//Faah-/ mice showed significantly improved neurogenesis in the hippocampus, indicated by a significant increase in neuroblasts and neuronal cells, an increase in BrdU+ cells and doublecortin positive cells (DCX+), and an increase in the number of PCNA.
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