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Indeed, our earlier microarray study comparing oocytes isolated from young mice with oocytes isolated from old mice shows only moderate gene expression changes with age: of around 22,000 genes examined there were only 99 genes with a more than two-fold change between old and young oocytes [ 18].
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As previously reported, FGF10-knockout mice show only small initial buds, which degenerate by E12.540.
When the Ptchd1 gene was knocked out only in the TRN, the mice showed only hyperactivity and attention deficits.
After 5 days of training, wild-type (WT) mice showed 60 70% active avoidance responses, whereas the DKO mice showed only 10 15% active avoidance responses.
At a time-point where Lyn−/− mice showed only mild autoimmune disease, Lyn−/−STAT6−/− mice had maximal titres of IgG and IgA auto-Abs, impaired renal function, myeloid expansion and a highly activated T cell compartment.
In fact, all the adult tissues of the genetically modified mice showed only EDA+ FN mRNA, demonstrating the fidelity of in vitro models, despite of the development- and aging-regulated splicing regulation of the EDA exon, and regardless of the presence of exonic elements described within the exon.
Human controls (HC) and control mice show only unspecific tracer retention across the whole brain.
Livers obtained from 50 nm GNP-treated mice showed only a moderate number of spots (d).
PA-Av-Alum and PA-Av/IFA immunized mice showed only 40 % and 30 survival, respectively.
In contrast, wildtype mice showed only a small increase that did not reach statistical significance.
In contrast, Atxn2 ko mice showed only minimal freezing (Fig. 3C).
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CEO of Professional Science Editing for Scientists @ prosciediting.com