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Remarkably, homozygous knock-in α8(Kiα3/Kiα3) mice fully prevented nuclear cataracts, while single knock-in α8(Kiα3/−) allele mice showed variable suppression of nuclear opacities in CrygbS11R/S11R mutant mice.
Breast tumours transplanted to nude mice showed variable responses to interferon (IFN -alpha and gamma.
About one-half of the tumours that developed in these mice showed variable histological patterns which included BL features [ 85] such as squamous/spindle cell differentiation, high nuclear grade, necrosis and lymphocytic infiltration [ 81].
Group C mice showed variable density of A β plaques, ±109 plaques/section), compared to A and B. Wild-type mice showed no A β deposits in any brain region (see squared area in Figure 2 (Grp C)).
As shown in Figure 4B, GFAP-IR astrocytes in the VPM/VPL of 90-week-old WT mice showed variable degrees of cellular hypertrophy, suggesting mild to moderate reactive astrogliosis.
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The VPAC2‐null mice show variable behavior with about half of the animals showing rhythmic behavior, and half lacking rhythmic behavior (Aton et al., 2005; Maywood et al., 2006, 2011; Brown et al., 2007).
Heterozygous mice at each age showed variable lens opacities ranging from clear (stage 0) at <2 months, stage 0 to stage 2 at 2 3 months, and clear to complete opacity (stage 4) at >4 months of age.
The old BALB/c mice used in these experiments showed variable deficiency in B lymphopoiesis, with loss of pre-B cells ranging from 11%to76%6% (average, 59% ± 7% SEM, n = 10).
A subset of the iTDP-43WT mice does survive until at least 12M; however, it is not uncommon for transgenic mice to show variable penetrance and survival rates, even when on an inbred background [ 1, 10, 11, 14].
Subclones showed variable engraftment potential in immunodeficient mice.
TZDs showed variable efficacy in studies of common cancers using xenograft and transgenic mouse models, in case studies and clinical trials (an overview is provided in Table 1).
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