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Furthermore, aged Lyn−/−STAT6−/− mice showed dramatically increased levels of serum IgE but minimal IgG1, suggesting that class-switching to IgE can occur in the absence of an IgG1 intermediate.
Cells derived from PyVT/ADN mice showed dramatically enhanced DNA synthesis under both 0.5% FBS and 10% FBS DMEM culture conditions.
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Studies in genetically modified mice revealed that: 1) a PR knockout mouse shows dramatically reduced susceptibility to carcinogenesis [ 15], 2) progesterone increases genomic instability in p53 null mouse models of breast cancer [ 16], and 3) treatment of Brca-1-deficient mice with the anti-progestin mifepristone (RU486) prevented mammary tumorigenesis [ 17].
When insulin release was measured after injection of glucose, Sei1-null mice showed a dramatically impaired secretion of insulin to the bloodstream (Fig. 7C).
Virtually across the entire light-dark cycle, HR mice showed a dramatically lowered level of SWA, while higher SWA was observed in LR animals (see Fig. 6).
We found that CHL1 /– mice showed a dramatically decreased mortality rate after they were subjected to AH (survival rate: 62.5% in CHL1−/− versus 12.5% in wild-type).
We found that, compared with wild-type littermates, CHL1−/− mice showed a dramatically lower mortality rate and an augmented ventilatory response after they were subjected to AH. Immunofluorescence staining revealed that CHL1 was expressed in the carotid body (CB), the key oxygen sensor in rodents, and CHL1 expression level in the CB as assayed by western blot was decreased after hypoxic exposure.
For use in a mice model, the as-prepared microcapsules showed dramatically enhanced MW thermotherapy outcomes in vivo.
In the most extreme cases, 17/47 (36%, containing on average 2.2 expression domains in zebrafish and 1.9 in mouse per CNE) of these sequences showed dramatically different patterns (divergence of expression for 75% or more anatomical domains).
Previous work from our laboratory showed dramatically increased expression and activation of PDGFRβ in aortas from smLRP1−/−; LDLR−/− mice on a high-cholesterol diet [7].
Correlating with this biochemical evidence, Cry1/Cry2-double-knockout mice show a dramatically elevated response to dexamethasone treatment.
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