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The resulting Ipf1/RAR403 tg mice showed complete pancreatic agenesis, lacking both dorsal and ventral pancreas, and died at the neonatal stage (Fig. 1d).
Since our DG/Lck-cre mice showed complete deletion of DG from mature naïve T cells, we studied the role of α-DG in mature activated T cells in the context of the proliferative response to allogeneic stimulation as well as the immune response to LCMV and influenza virus infections.
After sacrifice, the histopathological findings in each of these mice showed complete disappearance of the tumor and evidence of healing.
The middle and basal cochlear turns of kanamycin-treated mice showed complete loss of outer hair cells, while the inner hair cells remained largely intact.
Whereas experiments neutralizing IL-10 in the CNS only attenuated the effects of Th1-conditioned cells transfer, transfer of Th1-conditioned cells derived from il-10−/− mice showed complete abrogation of the restorative effects of Th1 cells.
In agreement with previously published data (LeBoeuf et al, 2011), Hdac1Δ/Δep and Hdac2Δ/Δep mice showed complete loss of the respective deacetylase, and were viable, fertile and displayed normal epidermal and HF development (Supplementary Figures S1C, D and J).
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These mice show complete absence of fore- and hindlimbs, and die after birth associated with complete absence of lungs.
Olig1/Olig2-null mice show complete failure of oligodendrocyte development, and the precursor cells destined for an oligodendrocyte fate differentiate instead into astrocytes [ 12].
These mice show complete uncoupling of synovial inflammation and bone erosion when arthritis is induced by overexpression of tumor necrosis factor (TNF) [ 14].
In line with this, the HBCx-17 xenograft showed a pronounced sensitivity to anthracycline-based chemotherapy with >50% of mice showing complete response (no tumour recurrence), as well as to cisplatin and ifosfamide combination.
In comparison, the D425Med tumours grew relatively slowly and responded well to temozolomide alone, with all mice showing complete tumour regressions, two of which were sustained until the termination of the experiment at 100 days.
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