By 26 hr post-injection, WT mice showed widespread MRI intensity increases that encompassed the contralateral thalamus, several cortical areas (especially the somatosensory cortex), and more basal anterior structures.
On day 14 and 23, H&E staining in the cross-sectional of the spinal cord of EAE mice showed widespread infiltration of inflammatory cells in the spinal cord (Fig. 4D F).
By 10 months APP-tg mice showed widespread endothelium damage, loss of cellular integrity and, in some sections, loss of endothelium in the wall of ventricles.
H&E-stained lung tissue from the OVA-challenged mice showed widespread eosinophil-rich inflammation in peribronchiolar and perivascular regions, and airspaces.
These mice showed widespread PrP plaques and the accumulation of a mixture of the intermediate type PrPSc with the 129M genotype (Mi PrPSc) and V2 PrPSc in the brain.
Despite the similarities in striatal expression changes at 18 months the HdhQ150 mice showed widespread mHTT and ubiquitin positive inclusion staining in the striatum whereas this was absent in the YAC128 striatum.
13 Analysis of DsRed expression in the high expresser G93Ros10-Sh1 line in 9 dpf larvae (which represent a similar developmental stage to the preweaning stages in mice) showed widespread stress in interneurons, but an absence of stress in motor neurons, suggesting that motor neurons do not show the HSR at the early larval stage of development (Supplementary Fig 4).
This mouse showed widespread T2 hyperintensity in the cerebellum with hydrocephalus.
In contrast, mice lacking ACh release and synaptic activity show widespread myofiber atrophy and degeneration of existing myotubes [13], [14].
Additionally, in the mouse, members of the TOLL-like receptor signalling pathway show widespread alternative splicing, which is thought to allow a higher level of diversity in the inflammatory pathway in response to pathogens [ 56].
