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Despite similar amounts of SMN (Figure 2B), kidney extracts from normal and carrier mice show very low Sm core formation compared with extracts from the CNS (Figure 3B) and the reduction in kidney extracts from severe SMA mice is more readily detected upon longer exposure of immunoprecipitation experiments (Figure S2).
Furthermore, the knockout mice show very subtle behavioral phenotypes with largely unaffected locomotion (2, 20).
Under normal conditions, the mdx mice show very few symptoms of the disease, and when subjected to intensive exercises, they present aggravation of the pathological alterations [ 2].
Indeed, as a prey species, mice show very few signs of discomfort, which might mislead investigators into thinking that high doses of a drug have no adverse effects.
More importantly, however, we found that in young (12 months) mice, plaque growth is directly related to the volume of a plaque (Fig. 6a), whereas most plaques in older (18 months) mice show very little, if any, growth (Fig. 6b).
Similar(55)
Intravenous and intraductal administration of AdTATMMP into mice showed very low AdTATMMP activity in the normal pancreas, whereas increased transduction was observed in pancreatic tumors of transgenic Ela-myc mice.
Moreover, CDDO-Im-treated mice showed very mild lymphadenopathy or lymphocyte infiltration into lungs.
Previous studies of hNOG mice showed very weak immune responses to viral antigens [8], [9], [11].
At all bacterial doses, WT mice showed very low mortality at 72 hours post-implantation (PI).
In contrast, wild-type mice showed very low levels of engraftment.
While the spleens of mice infected with LM-OVA showed a significant peak in OVA transcription at day 3 post-infection, spleens of ST-OVA infected mice showed very little OVA mRNA by day 7 post-infection (Fig. 10B).
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